Bioanalytical software to battle against bacterial diseases

Devastating pathogen-borne diseases and plagues in nature, both viral and bacterial, have affected humans since the beginning of human history.

Until the mid-20th century, bacterial pneumonia was probably the leading cause of death among elderly people. Improved sanitation, vaccines and antibiotics, have all decreased mortality rates from bacterial infections, although the war against bacterial diseases has no foreseeable end.

A study developed by experts at ECDC (European Centre for Disease Prevention and Control) and the Burden of AMR Collaborative Group,(Study published in The Lancet Infectious Diseases for EU/EEA journal) estimates that about 33.000 european people die each year as a direct consequence of an infection due to bacteria resistance to antibiotics. Furthermore, the burden of these infections, is comparable to that of influenza, tuberculosis and HIV/AIDS combined (https://ecdc.europa.eu/en/news-events/33000-people-die-every-year-due-infections-antibiotic-resistant-bacteria)

Even though many bacterial infections can be treated successfully with appropriate antibiotics, antibiotic-esistant strains are beginning to emerge, according to the World Health Organization. The antimicrobial resistance is occurring everywhere in the world, compromising capability to treat infectious diseases, as well as undermining many other advances in health and medicine. Full impact is unknown, there is no system in place to track antibiotic resistance globally, and many modern medicines could become obsolete.

As a consequence, common infections might become deadly threats. Therefore an accurate medical diagnosis is imperative for correct treatment, and hence to drecrease mortality and reuce lenght of hospitalization.

A rapid diagnosis also allows for early streamlining of empirical antimicrobial therapies, thus contributing to limit the emergence and spread of antimicrobial resistance. The introduction of MALDITOF mass spectrometry (MS) for routine identification of microbial pathogens has profoundly influenced microbiological diagnostics, and is progressively replacing biochemical identification methods.

Source: https://www.researchgate.net

Source: https://www.researchgate.net

In this context, digital revolution provided relatively inexpensive and available means to collect and store data. Thereby, with the right data analysis, implementation of MALDI-TOF mass spectrometry, as well as exponential growth of databases, enable clinical laboratories a very rapid microbial identification at low cost.

These advances have been a decissive to reach to successful medical diagnosis for the early treatment of patients.

In 2015 a group of engineers and an analytical chemistry specialist (among them several PhDs in different fields and with a wide expertise) founded a bioinformatics company named CLOVER BioSoft, based on the Granada Health Technology Park, specialized in Bionalytical Chemistry data analysis and Microbial ID, using Mass Spectrometry. This team aims to giving solutions to real problems using knowledge-based approaches, understanding data and the statistics behind it.

Using methods of artificial intelligence, machine learning and big data analysis, was born this cutting-edge project: Clover MS Strain Typing, a software solution developed to perform research on bacterial analysis applications using MALDI-TOF MS.

The software AI-powered algorithms allows to build smart and reliable analysis of the bacterial strain typing by studying differences in the lipidomic profiles of bacterial strains, using Mass Spectrometry. Identifying bacteria at the strain level is particularly important for diagnosis, treatment and epidemiological surveillance of bacterial infections.

Each feature included is the result of close interaction with experts, to provide the most efficient and convenient workflow, in order to answer bacterial analysis questions. Among others, the software features include:

• Repeatability and reproducibility studies for the validity of biological and technical replicates.
• Antibiotic resistance analysis comparing with positive and negative controls.
• Feature extraction: Strain class, resistance mechanism, bacteria type, etc.
• Samples identification: Strain typing prediction with custom database support.

 

Project strength relies on its specifically designed data processing algorithm, as well as a patented lipid extraction method to provide competitive advantage, which is a complete protocol already proven and demonstrated in multiple applications. It also has the major advantages of MALDI-TOF MS (speed, cost-efficiency), with the addition of the gradual decrease in size, and thus cost of mass spectrometers.

Current bacterial ID systems in the market using MALDI-TOF MS are decreasing time and cost in the detection of bacterial species. Extending these systems to the identification of individual strains will help applying the most appropriate antibiotics for every patient, having a more accurate treatment and fighting against antibiotic resistance. Moreover, this ID systems in the coming future will help to predict unknown cases by learning known multivariate data patterns.

Participation in the ACTTiVAte program has been decisive to accelerate project, making possible to reach to current state of business model 100% validated, with a marketed ready product. In this sense, it has resulted highly important the advice received in ACTTiVAte on strategy and business planning, through mentoring and coaching dynamics. In addition to the funding received through ACTTIVATE and the SME Instrument, Clover Biosoft will make use of reserved funds and forecasted sales to face the expenses generated by this feasibility study. They will also raise private investment to complement these H2020 programs.

Some specific goals of the feasibility study are:

• Technical feasibility: Perform initial evaluation with our partner hospitals to assess the potential to become a clinical product. Develop a technical, regulatory and validation plan. In order to get first national and international sales orders during year 2019.
• Clinical feasibility: Identify the most severe pathogen strains causing most of the infections in European hospitals. Define the clinical validation strategy.
• Business opportunity: Discover the best approach-to-market strategy and establish a continuous presence on the field. Study real market needs, size and potential for profit and scalability.
• Economic feasibility: Detailed economic analysis to reach the clinical market.

Concerning the future, brilliant perspectives arises, since this system may have extensive applications in different sectors, such as industrial chemistry, environmental testing, food & beverage testing, as well other
biotech applications such as mycobacterial ID, biomarkers for cancer, early detection of pressure ulcers and the Agrofood sector.

Musculoskeletal Disorders in different áreas – Osteoartritis / Source: https://sites.tufts.edu/humanfactorshiyuwang/2018/03/30/musculoskeletal-disorder/

Big Data to deal with Musculoskeletal Disorder

Musculoskeletal conditions affect people along their life everywhere. According to a study from the Global Burden of Disease, about 20-30% of worldwide population lives with a painful musculoskeletal condition.

While the prevalence of musculoskeletal conditions increases with age, younger people are also affected, often during their peak incomeearning years. Nowadays, Musculoskeletal Disorder (MSDs) are the most common reason of work disability, sick leave and early retirement of people under 50 all over the world, more than any other disease like cancer or diabetes.

MSDs, as the word already explains itself, is a kind of disorder affecting people’s musculoskeletal system, typically characterized by pain (often persistent pain) and limitations in mobility, dexterity and functional ability, reducing people’s ability to work and participate in social roles with associated impacts on mental wellbeing, and, at a broader level, impacting as well on prosperity of communities. Most common and disabling musculoskeletal conditions are osteoarthritis, back and neck pain, fractures associated with bone fragility, injuries and systemic inflammatory conditions, such as rheumatoid arthritis.

Musculoskeletal conditions share some similar risk factors to other non communicable diseases, such as inadequate physical activity, obesity, smoking and poor nutrition.

While management of some musculoskeletal conditions often requires specialist and/or surgical care, many musculoskeletal conditions can be managed in primary care services through a combination of core non-pharmacologic interventions, such as exercise, and psychological and pharmacologic therapies.

Moreover, health and broader social cost of musculoskeletal conditions are very relevant, although spending on musculoskeletal conditions is challenging to measure, due to the vast array of musculoskeletal conditions and limitations of surveillance systems.

According to the World Health Organization, MSDs conditions comprise more than 150 diagnoses which affect to the locomotor system. So hence, potential value of the annual sector is estimated around 300 trillion Dollars worldwide. Two thirds of this amount may derive from the costs saving for the National Health Service, and at a
European level this saving is estimated to be of 100 million Euros.

Bearing this context in mind, MDURANCE SOLUTIONS is a start-up based in Granada (Spain), part of the Technological trampoline network (CESEAND, RTT) and focused on the field of Digital Health.

Specifically, it’s been developed an auxiliary tool for the evaluation of musculoskeletal disorders (MSDs), based on an advanced analysis of signals generated by Electromyography (EMG Surface electromyography is the analysis of the electrical activity of muscles. Its aim is to detect and assess neuromuscular pathologies through the
evaluation of the health and performance of your patient’s musculature), and pursuing that this technique could be effectively used by Health professionals.

Main challenge of this project has consisted on unifying different technologies, such as Big Data, Wearables and Artificial Intelligence, to provide a deeper and more useful knowledge in the field of physical health and wellness. At the end, it’s been developed an intuitive digital tool designed to be used by a wide range of professionals, from the most expert specialist to a general physiotherapist in a high-performance sport center.

Wearable EMG sensor: Muscle activity controlled Source https://www.mdurance.eu

Wearable EMG sensor: Muscle activity controlled
Source https://www.mdurance.eu

Project mDurance is basically a wearable EMG sensor, integrated with an application for mobile devices, which sends signal data to a private cloud service, where all data are stored, processed and analysed through data mining and Big Data.

Over years of research, company has developed new algorithms to improve analysis. By applying these algorithms and AI technology to collected data, integrated system can provide reliable conclusions within only 5 minutes, being able to instantly detect the root cause of a patient’s problem. Thereby, it is possible to target the most effective treatment, providing so the highest impact therapy and shortening therefore the recovery period.

 

Main features of mDurance system might be summed up as follows:

• Biofeedback therapy: facilitating the process of learning exercises.
• Verify muscular anomalies.
• Objectively assess the muscle fatigue.
• Measure and objectively analyze muscle strength and development
• Detect muscle asymmetries: allowing to correct asymmetries in real time.
• Results processed in less than 30 seconds
• Access to results from any device.
• Build extensive reference material.
• Rapid assessments thanks to intuitive reports.
• Optimize peak performance times: reducing the likelihood of injury.

mDurance system interface in different devices: Muscle activity controlled Source https://www.mdurance.eu

mDurance system interface in different devices: Muscle activity controlled
Source https://www.mdurance.eu

One of the main factors for the project’s success has been the multidisciplinarity of the team, collecting knowledge and skills from different areas, which has been essential in the management and development of the project.

Another key factor has been the ACTTiVAte acceleration program, which facilitated to a large extent the boost of innovation. In this sense, although some parts of technology were developed and validated before joining to ACTTiVAte, however, acceleration carried out within program leaded to implement new functions, such as the
improvement in algorithms’ sensitivity and prediction capability, making possible to get ready mDurance for larger scale testing.

The main results of the development done within the ACTTiVAte project are:

• A new, very intuitive digital product CE Class II Certification.
• SME Instrument Phase 1.226.000 Euros from NEOTECNeotec Capital Riesgo.
• Cross4Health selected SMEs within its 2st Acceleration Programme. (mDurance will receive a voucher of up to
60.000 Euros to contract an external service to help boost their innovation)

Expectations from project are very high. Opportunity timing is clear, and project may help to palliate MSDs, improving life quality of many people.

ACTTiVAte, a reference in fostering cross-sectoral tech transfer

ACTTiVAte has directly promoted half a hundred cross-sectoral technology transfer projects, and laid the foundations for the development of new value chains involving different sectors and countries.

1.5 million euros of direct financing have been allocated to these SMEs, and 4.3 million euros in business support services (information, training and facilitation of access to relevant stakeholders, mainly).

The beneficiary SMEs have also been able to raise close to 1.7 million extra-funds in 2018, according to the information they have provided. This more than doubles the direct financial support provided by ACTTiVAte that year. In addition, they have invested about 4.5 million euros in their innovative projects, without including the ACTTiVAte funds.

These are just some of the quantitative results of the initiative, whose impact on SMEs is far-reaching. In fact, SMEs give ACTTiVAte a global score of 4.4 points out of 5 and SMEs appreciate the non-financial support received (especially training).

At the same time, ACTTiVAte offers a reference for the promotion of cross-sectoral technology transfer, carried out by European SMEs and with the aid of cluster organizations and other business support entities, as a means of stimulating and promoting regional innovation ecosystems.

The results of the initiative, along with the role of clusters, the challenge of cross-sectoral innovation and a selection of promising projects supported by ACTTiVAte, were presented at the final conference, under the title “Fostering cross-sectoral technology transfer in Europe: Lessons and prospects from the European project ACTTiVAte”. It took place at DES2019 (Madrid, 21st – 23rd May 2019).

One of the speakers, Mercedes Delgado, Associate Professor of Strategy and Innovation at Copenhagen Business School, and Research Scientist at the MIT Innovation Initiative, highlighted the figure of the “clusters as the key players for boosting innovation”. She detailed the main characteristics of the clusters and affirmed that they are everywhere and in every sector. Although she considers important to pay more attention to the traded industries (vs local industries), in terms of taking advantage of the benefits linked to cluster agglomerations, as well as identifying ecosystems and companies that are producing specialized inputs for other industries (more downstream linkages and more agglomeration benefits); so as not to create clusters from scratch, where there are still no companies. Then, to be located in appropriate ecosystems is vital for startups; as their performance depends not only on strategy, but also on location.

Anna Sobczak, EU policy-making expert for clusters and emerging industries at the European Commission (EC), stated that the EC is using clusters to support SMEs, taking into account that clusters are facilitators and bridge-builders for innovation. In the EU there are more than 3,000 strong regional clusters in related industries. The EC is promoting the building of bridges across European ecosystems through cluster partnerships, using three pillars: clusters as accelerators for innovation and industrial change, capacity building (Cluster Excellence Program), and inter-regional and international cluster cooperation. In addition, cross-sectoral collaboration has been one of the themes highlighted in the framework of the awareness-raising campaign across Europe on the role of clusters and their impact (developed between November 2018 and April 2019).

In the panel discussion on the cross-sectoral innovation the main stakeholders were represented: startups (through Vitulo Plus), clusters / sectoral support agencies (Oost NL), mentors / business advisors (Agnieszka Klucznik – Törö, ACTTiVAte mentor) and investors (Spain New Ventures Lead, Johnson&Johnson). They highlighted some key factors such as the importance of customer validation to bring an idea to the market, and of maintaining a continuous learning attitude and a global vision, among others. Regarding the clusters’ value, it was affirmed that clusters contribute with infrastructures to the needs of SMEs and facilitate their arrival to potential clients. They also bring and share values, and build relationships, making sure that SMEs get the right connections. Moreover, in relation to ACTTiVate, according to the CEO of Vitulo Plus, Gary Antonius, it has enable them to be quicker (time to maker was improved) and it has facilitated the access to complementary financing.

Also, nine SMEs supported by ACTTiVAte had the opportunity to present their projects at the event: Chamco (Agrofood & Health), CiTD (Aerospace & ICT), Clover BioSoft (ICT & Health), Destina Genomics (Health & Agrofood), DNActive (Health & Agrofood), Fastinov (Health & Agrofood), IXL (Health & Agrofood), Mater Dynamics (ICT & Agrofood) and mDurance (ICT & Health). Three of them (Chamco, DNA Active and Mater Dynamics), together with Vitulo Plus, also participated in a final round table in which various aspects of “the Journey through the project” were addressed.

By Afi, Analistas Financieros Internacionales

DOWNLOAD OUR SME’s BOOKLET: 

http://acttivate.eu/wp-content/uploads/2019/06/Booklet-ACTTiVAte.pdf

ACTTiVAte’s Final Conference at #DES2019. Madrid, May 22

The Digital Enterprise Show (DES2019) has been the framework chosen by the European project ACTTiVAte to celebrate its final conference under the title ‘Fostering cross-sectoral technology transfer in Europe: Lessons and prospects from the European project ACTTiVAte‘ with the assistance of the most relevant actors and a selected number of companies funded by this initiative.

Great success. Thanks to all!

Digital Enterprise Show is a global expo with over 300 world’s top tech companies, Congress with 450 world’s best digital experts, and 21,000 visitors, who gather every year in Madrid to discuss how the digital changes the business, to acquire the crucial knowledge, skills and solutions to shape their industries’ future.

DES has been the framework chosen by the European project ACTTiVAte to celebrate its final conference.

The ACTTiVAte initiative, promoted by the European Commission (Horizon 2020 research and innovation programme under grant agreement Nº 691473), with a duration of three years (ends next May 31), aims to boost the development of business ecosystems integrated by innovative SMEs and in which the transfer of technology among different key sectors is favored.

The Consortium is composed by thirteen members, six of them are Cluster organizations (or similar enabler entities).These clusters have played a key role, from the identification of potential beneficiary companies, to the monitoring of projects and direct support to SMEs. Madrid Aerospace Cluster is the coordinator.

ACTTiVAte has contributed to the development of 50 cross-sectoral technology transfer projects, involving six participating countries (Spain, Portugal, The Netherlands, Belgium, Ireland and Poland) and four sectors (Aerospace, Agrofood, Health and ICT), with 1.5 million euros of direct financing to SMEs and an extra 4.3 million euros in Business Support Services such as information, training and networking / access to stakeholders…

All projects have achieved important progress in several fields linked to SME development mainly in relation to training, strategic skills development, networking and innovation process improvement.

Final General Assembly Meeting, Dublin

DES 2019: Digital Enterprise Show

• The European project ACTTiVAte will be at the Digital Enterprise Show, the world’s leading event dedicated to Digital Transformation in Madrid, 21-23 May 2019 (IFEMA Hall 8 – Stand D407)
• Under the title ‘Fostering cross-sectoral technology transfer in Europe: Lessons and prospects from the European project ACTTiVAte’ , will celebrate its Final Conference on May 22.

Digital Enterprise Show is a global expo with over 300 world’s top tech companies, Congress with 450 world’s best digital experts, and 21,000 visitors, who gather every year in Madrid to discuss how the digital changes the business, to acquire the crucial knowledge, skills and solutions to shape their industries’ future.

DES has been the framework chosen by the European project ACTTiVAte to celebrate its final conference.

The ACTTiVAte initiative, promoted by the European Commission (Horizon 2020 research and innovation programme under grant agreement Nº 691473), with a duration of three years (ends next May 31), aims to boost the development of business ecosystems integrated by innovative SMEs and in which the transfer of technology among different key sectors is favored.

The Consortium is composed by thirteen members, six of them are Cluster organizations (or other enabler entities).These clusters have played a key role, from the identification of potential beneficiary companies, to the monitoring of projects and direct support to SMEs. Madrid Aerospace Cluster is the coordinator.

ACTTiVAte has contributed to the development of 50 cross-sectoral technology transfer projects, involving five participating countries (Spain, Portugal, The Netherlands, Ireland and Poland) and four sectors (Aerospace, Agrofood, Health and ICT), with 1.5 million euros of direct financing to SMEs and an extra 4.3 million euros in Business Support Services such as information, training and networking / access to stakeholders…

All projects have achieved important progress in several fields linked to SME development mainly in relation to training, strategic skills development, networking and innovation process improvement.

Coinciding with the end of this initiative, ACTTiVAte’s Final Conference will be held on May 22, under the title ‘Fostering cross-sectoral technology transfer in Europe: Lessons and prospects from the European project ACTTiVAte‘ with the assistance of the most relevant actors and a selected number of companies funded by this initiative, which will present their projects.

Download the Press release here.

ACTTiVAte’s Innovation Forum in Porto

Last Friday took place the Workshop: ‘Transfer of technologies as a path to innovation in the health and agrifood sectors’, organized by INEGI at Alfândega do Porto (Portugal).


Eugenio Fontán from Madrid Aerospace Cluster (ACTTiVAte’s coordinator) presented the ACTTiVATe project. Luís Pina, INEGI’s Research Coordinator, gave an overview of the projects funded by ACTTiVAte, and several SMEs presented their demonstrative prototypes of the technologies that have been transferred to the health and agrifood sectors:

  • Luisana Carvalho from IncreaseTime presented ESCaPe, a T-shirt with integrated sensors in the fabric, a telehealth system that allows continuous monitoring of the cardiovascular patients. More information
  • Robert Pater from HealthSens presented CoolPet to medical device, HealthSens fever monitor ICT to medical device transformation. More information
  • Luís Bastião from BMD software presented NetPathology, a digital platform that promises to facilitate the work of pathologists. More information
  • Alfredo Silva  from  Inova + presented BloC@ST, Protection of sensitive patient data using an innovative multi-layer blockchain approach. More information
  • Nélson Oliveira from BestHealth4U, presented Bio2Skin, a novel glue-less adhesive solution for medical applications avoiding skin injury in prolonged use or upon removal. More information
  • Ferdinando França Andrade from FASTINOV, presented FAST-vet a Flow cytometry Antimicrobial Susceptibility Test for Veterinary. More information
  • Tiago Cunha Reis from Mater Dynamics presented QStamp, passive and wireless flexible sensors for the Agrifood sector. More information
  • Gary Antonius from VKON
  • Artur Thielmann from Fine Bubble Technologies presented BubbleFoot, a treatment of diabetic foot by bathing in water enriched with carbon dioxide nanobubbles. More information

Afterwards, a discussion was promoted with Portuguese and European public funding agencies and innovation investment funds on the existing funding mechanisms for technology transfers through two round tables: ‘Innovation in Health sector – from SMEs to big corporates’ was attended by Luís Soares (Strategy Director – Health Cluster Portugal), Rita Ralha (Innovation Lead – Grupo José de Mello Saúde) and Ricardo Cruz Correia (Co-founder – HealthySystems); ‘MDevNet: National Network for Knowledge Transfer on Medical Devices’ was attended by Nuno Felício (MDevNet Project Manager/ Fraunhofer Portugal AICOS) and ‘Financing mechanisms for innovative SMEs’ was attended by Alexandre Marques (GPPQ/ ANI – Portuguese National Innovation Agency).

The event ended with B2B meetings with companies from the two sectors.

Workshop: Innovation through cross-sectoral technology transfer in the Health & Agrifood sectors. March 8, Porto.

Get to know these and other companies supported by the Acttivate project in the “Workshop: Transfer of technologies as a path to innovation in the health and agro-food sectors“, which is held on March 8th in Porto.

ESCaPe a telehealth system that allows continuous monitoring of the cardiovascular patients. Increase Time has developed a T-shirt with integrated sensors in the fabric.

FAST-VET low cytometry Antimicrobial Susceptibility Test for Veterinary: This project consists in the assesment of antimicrobial susceptibility for bacterial in the veterinary area.

BestHealth4U has created Bio2skin, a biopolymer developed to have adhesion characteristics.

BMD Software has created a digital platform that promises to facilitate the work of pathologists.

Connect Robotics has developed a drone container that can track and maintain the internal temperature and humidity, to transport medicines in compliance with the industry best practices.

B2B Brokerage & Event on Cross-Sectoral Technology Transfer to/from the Aerospace Sector

On February 21 took place the ACTTiVAte’s B2B Brokerage & Event on Cross-Sectoral Technology Transfer to/from the Aerospace Sector, at IESE Campus, Madrid.

The welcome and presentation of the event was given by Juan Luis Segurado, Senior Lecturer in the Entrepreneurship Department of IESE Business School and Eugenio Fontán, Managing Director of Madrid Aerospace Cluster, ACTTiVAte’s project coordinator.

Invited guests from Aerospace industrial companies and public administration discussed their relation with innovative SMEs: Alejandro Arranz, Madrid Regional Government General Director for Research and Innovation, spoke about the regional ecosystem to support innovation. Miguel Gasco, from Accenture, explained how to work with big players in the Aerospace sector; Luis Guerra, from CDTI (Centre for the Development of Industrial Technology) described the European instruments for supporting SMEs; and Vanesa Ramos from KIM (Knowledge Innovation Market) spoke about European Space Agency (ESA) brokerage opportunities.

Likewise, Pawel Pacek, Vice director of the Office of Development and Innovation, Industry Development Agency of Poland,  presented the Open Innovation Network (Sieć Otwartych Innowacji) project, addressed to companies from the space sector that were present at the B2B Brokerage Event.

The ACTTiVAte project case studies.

During the second part of the event took place the presentation of the results from several demonstrative cross-sectoral technology transfer projects, to and from the Aerospace sector:

  • José María Barranco, from Sertec, presented PETRA, an eye tracking system to monitor the stress of the pilots.
  • José Gomes from Critical Materials presented AR-SHM, Augmented Reality framework for exploitation of Structural Health Monitoring system information.
  • Lidia Hernández, from CITD, presented PAMIS, Personalized additive manufactured implants for scoliosis treatment.
  • Rafael Olmedo, from Geko Navsat, presented GENIO, a marketable an affordable GNSS advanced solution for blind people.
  • And Cristina Porcel from SkanSense presented FARSIGHTS, that solves the problem of current object detection technologies with a patented technology to locate fully automatically objects in satellite imagery

Download the presentations:

 

PAMIS: Personalized additive manufactured implants for scoliosis treatment

PAMIS is one of the 50 ACTTiVAte selected projects resulting from the advanced technologies transfer among aerospace and health sectors.

In severe cases of scoliosis surgery may be needed to prevent progression and/or correct the spine curve to avoid physical problems. Scoliosis surgery is linked to the implantation of standard straight/flat metallic straps (titanium, Cr/Co), with several holes, screwed to the spine. The position and number of straps is defined by the expertise of the surgeon.

3D digital model and structure optimization has been a challenge in the aerospace industry for the last 20 years. Scoliosis surgery implants could be functional, shape and topologically optimized, always looking for a uniform stress distribution. Thanks to the possibility of working with 3D scan CAD models of the spine, finite element modeling and design optimization techniques can be applied.

This new concept of optimized implants can help to improve these cases of severe scoliosis improving the rate on the life quality test for the patients and giving economical savings to the health system due to the reduction of post surgery issues. It is as well an opportunity to take advantage of the “digital twin” concept to prepare scoliosis surgery and implants.

This pairing of the virtual and physical worlds allows heading off problems before they even occur in the surgery. The virtual human model concept and new definition of bio-inspired 3D printed parts for scoliosis could open the way to the definition of other lines of orthopedic implants and the application of materials better suited to the specific stress to correct in each case.

More information: http://acttivate.eu/projects/pamis